5 Minute Journal: Second Antibiotic Delays in Sepsis

Author: Dr. Tisma Background/Study Question How often do septic patients receive their second antibiotic dose later than they should? What are the risk factors for these delays? And do these delays affect patient outcomes? Leisman et. al. published a study in 2017 that examined these important inquiries. These questions are particularly interesting to me as

5 minute Journal: Hydrocortisone + Fludrocortisone for adults with septic shock

Author: Vanessa I. Petrak, M.D. Background: Septic Shock is a dysregulated host response to infection, resulting in life-threatening circulatory, cellular, and metabolic abnormalities. Sepsis is associated with a dysregulated response of the hypothalamic-pituitary-adrenal axis that may involve any of the steps from cortisol production to cortisol use by cells. Short term mortality is approximately 45-50%, and

5 minute Journal: Shocking Norepi Use

Author: Dr. Collin Wulff, DO Study Question: Does early low-dose norepinephrine improve shock control in those with sepsis with hypotension? Design: Mostly good buzzwords here; single center, randomized, double-blind, placebo controlled clinical trial, smallish study (310 total). The study group received a fairly low dose of norepi infusion (0.05 mcg/kg/min). The primary outcome was not

5 Minute Journal: Central Line Placement

Author:  Lauran Wirfs

Background:

Central venous access is an important procedure for critically ill patients. One consideration when placing a venous catheter is the risk of catheter-related bloodstream infections (CRBIs), which can be a significant cause of morbidity and mortality in hospitalized patients. In 2012, there were 15 million central venous catheter (CVC) days per year in the US in ICUs, and the rate of infections per catheter days is 3/1000. This post looks at a systematic review done by Marik et. al. that examines CRBIs among internal jugular, subclavian, and femoral central venous sites.

PALS 2010

Kleinman et al, “Part 14: Pediatric Advanced Resuscitation.” Circulation. November 2, 2010. (Supplement). It’s available free online, go grab a copy and enjoy with a nice cup of coffee. Introduction Airway Monitoring and Access Drugs (part 1) Drugs (part 2) Pulseless Arrest Bradycardias Tachycardias